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Did You Know: Creatine is the number-one sports performance supplement available.
Yet despite its research-backed benefits, some people avoid creatine because they’re afraid it’s bad for health.
Some claim it causes weight gain, cramping, and digestive, liver, or kidney problems.
What Are Its Purported Side Effects?
Depending on who you ask, the suggested side effects of creatine may include:
Additionally, some people wrongly claim that creatine is an anabolic steroid, that it’s unsuitable for women or teenagers, or that it should only be used by professional athletes or bodybuilders.
Despite the negative press, the International Society of Sports Nutrition regards creatine as extremely safe, concluding that it is one of the most beneficial sports supplements available.
Leading researchers who have studied creatine for several decades also conclude that it is one of the safest supplements on the market (Long-term creatine supplementation does not significantly affect clinical markers of health in athletes).
One study examined 52 health markers after participants took creatine supplements for 21 months. It found no adverse effects.
Creatine has also been used to treat various diseases and health problems, including neuromuscular disorders, concussions, diabetes, and muscle loss (, Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice, ~~~Oral creatine supplementation in Duchenne muscular dystrophy: a clinical and 31P magnetic resonance spectroscopy study,~~~ Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization).
Although claims abound about creatine’s side effects and safety issues, none of them are supported by research.
What Does It Do in Your Body?
Creatine is found throughout your body, with 95% stored in your muscles (Creatine: a dietary supplement and ergogenic aid).
It is obtained from meat and fish and can also be produced naturally in your body from amino acids (Clinical pharmacology of the dietary supplement creatine monohydrate).
However, your diet and natural creatine levels do not normally maximize muscle stores of this compound.
The average stores are about 120 mmol/kg, but creatine supplements can elevate these stores to around 140–150 mmol/kg (Muscle creatine loading in men).
During high-intensity exercise, the stored creatine helps your muscles produce more energy. This is the main reason that creatine enhances exercise performance ~~~(Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans).
Once you fill your muscle’s creatine stores, any excess is broken down into creatinine, which is metabolized by your liver and excreted in your urine.
Around 95% of the creatine in your body is stored in your muscles. There, it provides increased energy for high-intensity exercise.
Does It Cause Dehydration or Cramps?
Creatine alters your body’s stored water content, driving additional water into your muscle cells (Effects of training and creatine supplement on muscle strength and body mass).
This fact may be behind the theory that creatine causes dehydration. However, this shift in cellular water content is minor, and no research supports the claims about dehydration.
A three-year study of college athletes found that those taking creatine had fewer cases of dehydration, muscle cramps, or muscle injuries than those not taking it. They also missed fewer sessions due to illness or injury (Creatine supplementation during college football training does not increase the incidence of cramping or injury).
One study examined creatine use during exercise in hot weather, which can accelerate cramping and dehydration. During a 35-minute cycling session in 99°F (37°C) heat, creatine had no adverse effects compared to a placebo (Physiological responses to short-term exercise in the heat after creatine loading).
Further examination via blood tests also confirmed no difference in hydration or electrolyte levels, which play a key role in muscle cramps (Physiological responses to short-term exercise in the heat after creatine loading).
The most conclusive research has been conducted in individuals undergoing hemodialysis, a medical treatment that may cause muscle cramps. Researchers noted that creatine reduced cramping incidents by 60% (Creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis).
Based on the current evidence, creatine does not cause dehydration or cramping. If anything, it may protect against these conditions.
Contrary to popular belief, creatine does not increase your risk of cramps and dehydration — and, in fact, may reduce your risk of these conditions.
Does It Cause Weight Gain?
Research has thoroughly documented that creatine supplements cause a quick increase in body weight.
After one week of high-dose loading of creatine (20 grams/day), your weight increases by around 2–6 pounds (1–3 kg) due to increased water in your muscles ( Effects of creatine supplementation on body composition, strength, and sprint performance).
Over the long term, studies show that body weight may continue to increase to a greater extent in creatine users than in non-creatine users. However, weight gain is due to increased muscle growth — not increased body fat (Effect of creatine supplementation on body composition and performance: a meta-analysis).
For most athletes, the additional muscle is a positive adaptation that may improve sports performance. As it is also one of the main reasons people take creatine, it should not be considered a side effect (International Society of Sports Nutrition position stand: creatine supplementation and exercise,
Increased muscle may also have benefits for older adults, obese individuals, and those with certain diseases (The underappreciated role of muscle in health and disease,
Weight gain from creatine is due not to gaining fat but to increased water content within your muscles.
How Does It Affect Your Kidneys and Liver?
Creatine can slightly raise levels of creatinine in your blood. Creatinine is commonly measured to diagnose kidney or liver problems.
However, the fact that creatine raises creatinine levels does not mean that it is harming your liver or kidneys (Is the use of oral creatine supplementation safe).
To date, no study of creatine use in healthy individuals has provided evidence of harm to these organs (Adverse effects of creatine supplementation: fact or fiction, ~~~Effect of oral creatine supplementation on urinary methylamine, formaldehyde, and formate,~~~ Creatine supplementation and health variables: a retrospective study, Effect of short-term high-dose creatine supplementation on measured GFR in a young man with a single kidney).
A long-term study of college athletes found no side effects related to liver or kidney function. Other studies measuring biological markers in the urine also found no difference after creatine ingestion (Effects of long-term creatine supplementation on liver and kidney functions in American college football players).
One of the longest studies to date — lasting for four years — similarly concluded that creatine has no negative side effects (Creatine supplementation and health variables: a retrospective study).
Another popular study often cited in the media reported kidney disease in a male weightlifter who supplemented with creatine.
However, this single case study is insufficient evidence. Numerous other factors, including additional supplements, were also involved (Effect of short-term high-dose creatine supplementation on measured GFR in a young man with a single kidney, ~~~Acute renal failure in a young weight lifter taking multiple food supplements, including creatine monohydrate).
That said, creatine supplements should be approached with caution if you have a history of liver or kidney issues.
Current research suggests that creatine does not cause liver or kidney problems.
Does It Cause Digestive Problems?
As with many supplements or medications, excessive doses may cause digestive issues.
In one study, the 5-gram recommended dose caused no digestive problems, while a 10-gram dose increased diarrhea risk by 37% (Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent).
For this reason, the recommended serving is set at 3–5 grams. The 20-gram loading protocol is also split into four servings of 5 grams each over the course of a day.
One leading researcher reviewed several studies and concluded that creatine does not increase digestive problems when taken at recommended doses (Analysis of the efficacy, safety, and regulatory status of novel forms of creatine).
However, it is possible that additives, ingredients, or contaminants generated during the industrial production of creatine can lead to issues (Is the use of oral creatine supplementation safe).
It is therefore recommended that you purchase a trusted, high-quality product.
Creatine does not increase digestive issues when the recommended dosages and loading guidelines are followed.
How Does It Interact With Other Drugs?
As with any diet or supplement regimen, it is best to discuss your creatine plans with a doctor or other medical professional before you start.
You may also wish to avoid creatine supplements if you are taking any medications that affect liver or kidney function.
Medications that may interact with creatine include cyclosporine, aminoglycosides, gentamicin, tobramycin, anti-inflammatory drugs like ibuprofen, and numerous others (7).
Creatine can help improve blood sugar management, so if you are using medication known to affect blood sugar, you should discuss creatine use with a doctor (Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization).
You should also consult a medical professional if you are pregnant, breastfeeding, or have a serious condition, such as heart disease or cancer.
SUMMARYCreatine may cause problems if you take certain types of medications, including medications that affect blood sugar.
Other Potential Side Effects
Some people suggest that creatine can lead to compartment syndrome, a condition that occurs when excessive pressure builds inside an enclosed space — usually within arm or leg muscles.
Although one study found an increase in muscle pressure during two hours of heat training, it resulted mainly from heat and exercise-induced dehydration — not from creatine.
Researchers also concluded the pressure was short-lived and insignificant.
Some claim that creatine supplements increase your risk of rhabdomyolysis, a condition in which muscle breaks down and leaks proteins into your bloodstream. However, this idea is not supported by any evidence.
The myth originated because a marker in your blood called creatine kinase increases with creatine supplements.
However, this slight increase is quite different from the large amounts of creatine kinase associated with rhabdomyolysis. Interestingly, some experts even suggest creatine may protect against this condition (Safety of creatine supplementation, ~~~Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration).
Some people also confuse creatine with anabolic steroids, but this is yet another myth. Creatine is a completely natural and legal substance found in your body and in foods — such as meat — with no link to steroids (Clinical pharmacology of the dietary supplement creatine monohydrate).
Finally, there is a misconception that creatine is suitable only for male athletes, not for older adults, women, or children. However, no research suggests that it is unsuitable in recommended doses for women or older adults.
Unlike most supplements, creatine has been given to children as a medical intervention for certain conditions, such as neuromuscular disorders or muscle loss.
Studies lasting as long as three years have uncovered no negative effects of creatine in children ( Oral creatine supplementation in Duchenne muscular dystrophy: a clinical and 31P magnetic resonance spectroscopy study,~~~ Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy).
Research has consistently confirmed creatine’s excellent safety profile. There is no evidence that it causes adverse conditions like rhabdomyolysis or compartment syndrome.
Creatine has been used for more than a century, and over 500 studies support its safety and effectiveness.
At the end of the day, creatine is one of the cheapest, most effective, and safest supplements available.